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KMID : 0350519950480010157
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Journal of Catholic Medical College
1995 Volume.48 No. 1 p.157 ~ p.167
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The Effect of Desmopressin Acetate on Coagulation in Rabbits Subjected to Severe Hemorrhagic Shock
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Abstract
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Desmopressin acetate(DDAVP) is a synthetic analogue of vasopressin that may improve hemostasis in congenital or acquired disorders of coagulation and it reduces operative blood loss in patients undergoing certain surgical procedures. The effects
of
DDAVP on coagulation in hemorrhagic shock were studied in rabbits subjected to severe hemorrhage. 20 rabbits were bled to shock and infused into the lactated Ringer's solution simultaneously so that the mean arterial pressure was maintained above
50
mmHg. Animals were randomly received DDAVP 0.3㎍/kg(group D1), 3㎍/kg(group D10) or saline(group S) over 15 minutes. Bleeding time and factorⅧ coagulant activity(FⅧ : C)
@ES The results were as follows ;
1) After shock, bleeding time was not significantly changed but FⅧ : C was significantly decreased in all groups.
2) After saline or DDAVP infusion, bleeding time was not changed in group S and group S and group D1, whereas shortened in group D10 from 107.5±11.3 sec to 87.5±17.5 sec(P<0.05).
3) After saline of DDAVP infusion, FⅦ : C was decreased in group S and group D1(P<0.05), but not changed in group D10. And the change of FⅦ : C after infusion in group D10 was + 7.0%, compared to -17.6% in group S, -17.1% in group D1(P0.001).
In conclusion, the infusion of DDAVP 3㎍/kg causes an increase in FⅧ : C and it shortens bleeding time in rabbits resuscitated from hemorrhagic shokc while DDAVP 0.3㎍/kg does not change bleeding time or FⅦ : C.
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